COLLABORATIVE WORK TO EVALUATE TOXICITY ON MALE REPRODUCTIVE ORGANS BY REPEATED DOSE STUDIES IN RATS : 20)TESTICULAR TOXICITY OF NITROFURAZONE AFTER 2 AND 4 WEEKS
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چکیده
منابع مشابه
Collaborative Work to Evaluate Toxicity on Male Reproductive Organs by Repeated Dose Studies in Rats
Nitrofurazone (NF) has been previously demonstrated to induce testicular toxicity with 4 weeks of oral administration in rats, ln the present study, rats were administered NF to assess whether testicular toxicity becomes evident with a 2-week administration period, Male Sprague-Dawley rats were administered oral doses of NF at 50 mgfkg fbr 2 or 4 weeks. Another group was administered NF at 100 ...
متن کاملCollaborative Work to Evaluate Toxicity on Male Reproductive Organs by Repeated Dose Studies in Rats
m [Ib assess the eencacy of difTerent period of treatment fbr evaluating male reproductive toxicity in rats, reserpine was subcutaneously administered on a daily basis to male Sprague-Dawley rats at dosages of O.05, O.1 or O.2 mgfkg for 2 weeks or at dosages of O,05 or O, 1 mglkg fbr 4 weeks. At the end of the administration period the animals were sacrificed and sperm counts, organ weights and...
متن کاملCollaborative work to evaluate toxicity on male reproductive organs by repeated dose studies in rats 27). Repeated toxicity study on ethylene glycol monomethyl ether for 2 and 4 weeks to detect effects on male reproductive organs in rats.
As part of a collaborative project to determine the minimum administration period to detect compound effects on male reproductive organs in Sprague-Dawley (Crj:CD(SD)) male rats, 6- and 8-week-old rats were administered ethylene glycol monomethyl ether (EGME) daily at 100 and 200 mg/kg/day for 2 weeks or 100 mg/kg/day for 4 weeks, and histopathological changes in the testes and epididymides wer...
متن کاملCollaborative work to evaluate toxicity on male reproductive organs by repeated dose studies in rats 13). Effects of a single oral dose of cyclophosphamide.
As part of a collaborative effort to evaluate whether effects on male reproductive organs of chemicals can be detected within two-week in toxicity studies, eight-week-old male Sprague-Dawley rats were given a single oral administration of 100 mg/kg of Cyclophosphamide (Cp), and sacrificed at 1, 3, 7 and 14 days thereafter. The numbers of seminiferous epithelial cells were counted in the seminif...
متن کاملCollaborative work to evaluate toxicity on male reproductive organs by repeated dose studies in rats 19). Effects of two-week repeated dosing of enoxacin on the male reproductive organs.
The toxicity of Enoxacin (ENX), a fluoroquinolone antibacterial agent, on the testis and epididymis was studied in rats. ENX was administered to 5 male rats orally once daily for 2 weeks at the dose level of 3000 mg/kg/day. ENX-treated rats showed a marked decrease in body weight, and two of them died on Day 10. At the end of the dosing period, absolute weights of the epididymis were decreased;...
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ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 2000
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.25.specialissue_195